Many bacteria conditionally express proteinaceous organelles referred to here as microcompartments (Fig. 1). These microcompartments are thought to be involved in a least seven different metabolic processes and the number is growing. Microcompartments are very large and structurally sophisticated. They are usually about 100–150 nm in cross section and consist of 10,000–20,000 polypeptides of 10–20 types. Their unifying feature is a solid shell constructed from proteins having bacterial microcompartment (BMC) domains. In the examples that have been studied, the microcompartment shell (...) encases sequentially acting metabolic enzymes that catalyze a reaction sequence having a toxic or volatile intermediate product. It is thought that the shell of the microcompartment confines such intermediates, thereby enhancing metabolic efficiency and/or protecting cytoplasmic components. Mechanistically, however, this creates a paradox. How do microcompartments allow enzyme substrates, products and cofactors to pass while confining metabolic intermediates in the absence of a selectively permeable membrane? We suggest that the answer to this paradox may have broad implications with respect to our understanding of the fundamental properties of biological protein sheets including microcompartment shells, S‐layers and viral capsids. BioEssays 30:1084–1095, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

Rather than seeking support from the massive scholarly work on the 13th century thinker, Bobik (philosophy, U. of Notre Dame) translates and interprets Aquinas' work on the principles of nature and on the mixture of elements, and uses them as a basis for independent philosophy on the relationship between form and matter in the context of God's creative causality. Paragraphs of the Latin originals are followed by English versions, then Bobik's commentary. Annotation copyrighted by Book News, Inc., Portland, (...) OR. (shrink)

In Aquinas on Being and Essence: A Translation and Interpretation, Joseph Bobik interprets the doctrines put forth by St. Thomas Aquinas in his treatise On Being and Essence. He foregrounds the meaning of the important distinction between first and second intentions, the differing uses of the term “matter,” and the Thomistic conception of metaphysics.

_Jokes, Life after Death, and God _has two main tasks: to try to understand exactly what a joke is, and to see whether there are any connections between jokes, on the one hand, and life after death and God, on the other hand. But it pursues other tasks as well, tasks of an ancillary sort. This book devises a general and comprehensive, but brief, theory of jokes. The author begins with critiques of other writers’ views on the subject. 1) Ted (...) Cohen thinks that such a theory is impossible. 2) Ronald Berk, on the other hand, provides just such a theory. And 3) John Morreall provides a general theory of laughter, which may include some things which can be used in a general theory of jokes. 4) Neil Schaeffer, too, provides a general theory of laughter, which makes a big point out of what he calls the “ludicrous context”; but he does include a chapter on jokes. 5) Christopher Wilson offers a general theory of jokes in which he focuses on form and content. And 6) Thomas Werge, in reflecting on the comic, suggests a general theory of jokes which identifies their matter, form, agents, purposes, and beyond these, the underlying shared relational context, which makes it possible for jokes to arise. 7) Bill Fuller’s message is that there is more funniness coming out of two or more heads than out of one, just as Socrates’ message was that there is more clarity coming out of two or more heads than out of one. 8) Umberto Eco feels that monks should laugh, just as ordinary people do; for laughter not only refreshes our seeking spirits, it also illuminates the truth we seek. 9) Simon Critchley, in his reflections on humor, notes that jokes bring on a kind of everyday anamnesis, that they are anti-story stories, that they are like prayers, that they are like philosophy; and that they require a certain underlying context, which is implicitly recognized by both teller and listener, and which renders possible the tension needed to make the punch line work. 10) Martha Wolfenstein, pursuing a psychological analysis of children’s humor, proposes that the underlying motive for telling jokes remains the same from childhood to adulthood, i.e., to transform painful and frustrating experiences so as to extract pleasure from them; and that the agent or productive cause of jokes is the repressing unconscious, as suggested by Freud. As John Morreall has argued, neither the Superiority Theory, nor the Relief Theory, nor the Incongruity Theory appears to work as a general and comprehensive theory. Moreover, these writers talk more about humor and laughter than about jokes. To be sure, a joke is a type of humor. Thus, to say something about humor is to say something, though of a generic sort, about jokes. Similarly, to say something about the laughter caused by humor is to say something, though generic, about the laughter caused by jokes. Most of the authors considered in chapter one are concerned with jokes, and not only with humor as such. Section 11 of chapter one puts together, out of the combined contributions of these authors, what can be considered the beginnings of, some thoughts toward, a general and comprehensive theory of jokes. This task the author illustrates in a concrete way, by looking at individual jokes of different sorts; not, however, without inviting the reader to enjoy these jokes. The author looks particularly at Jewish jokes, Christian jokes, and Islamic jokes, jokes about philosophy and philosophers, yo mama jokes, Italian jokes and Slovak jokes, all of which makes for a clearer understanding of exactly what a joke is. The analysis of general theory is then followed by some views on the morality of jokes and joke-telling, and an analysis of the connection between jokes and life after death, on the one hand, and God, on the other. Throughout the book Bobik offers innumerable examples to heighten our understanding and entertain us. (shrink)

Beginning with a Cuban Catholic ritual in Miami, this book takes readers on a momentous theoretical journey toward a new understanding of religion.

"Unabridged and unaltered republication of the work originally published ... in 1950." Bibliographical footnotes.

Non-epistemic values play important roles in classificatory practice, such that philosophical accounts of kinds and classification should be able to accommodate them. Available accounts fail to do so, however. Our aim is to fill this lacuna by showing how non-epistemic values feature in scientific classification, and how they can be incorporated into a philosophical theory of classification and kinds. To achieve this, we present a novel account of kinds and classification, discuss examples from biological classification where non-epistemic values play decisive (...) roles, and show how this account accommodates the role of non-epistemic values. (shrink)

Natural kinds are often contrasted with other kinds of scientific kinds, especially functional kinds, because of a presumed categorical difference in explanatory value: supposedly, natural kinds can ground explanations, while other kinds of kinds cannot. I argue against this view of natural kinds by examining a particular type of explanation—mechanistic explanation—and showing that functional kinds do the same work there as traditionally recognized natural kinds are supposed to do in “standard” scientific explanations. Breaking down this categorical distinction between traditional natural (...) kinds and other kinds of kinds, I argue, delivers two goods: It provides us with a view of natural kindhood that does justice to the epistemic roles of kinds in scientific explanations. And it allows us to solve a problem that HPC theory, currently one of the more popular accounts of natural kindhood, confronts. (shrink)

This work argues for the need to close the gap between the fields of the philosophy of religion and religious studies. Thomas A. Lewis takes up what, in recent years, has often been seen as a fundamental reason for excluding religious ethics and philosophy of religion from religious studies: their explicit normativity. Against this presupposition, Lewis argues that normativity is pervasive--not unique to ethics and philosophy of religion--and therefore not a reason to exclude them from religious studies. He bridges (...) more philosophical and historical subfields by arguing for the importance of history to the philosophy of religion. He considers the future of religious ethics, explaining that the field as whole should learn from the methodological developments associated with recent work in comparative religious ethics and 'comparative religious ethics' should no longer be conceived as a distinct subfield. The concluding chapter engages broader, post-9/11 arguments about the importance of studying religion, arguing that prominent contemporary notions of 'religious literacy' actually hinder our ability to grasp the significance of religion and impact in the world today. (shrink)

Natural kinds are often contrasted with other kinds of scientific kinds, especially functional kinds, because of a presumed categorical difference in explanatory value: supposedly, natural kinds can ground explanations, while other kinds of kinds cannot. I argue against this view of natural kinds by examining a particular type of explanation—mechanistic explanation—and showing that functional kinds do the same work there as traditionally recognized natural kinds are supposed to do in “standard” scientific explanations. Breaking down this categorical distinction between traditional natural (...) kinds and other kinds of kinds, I argue, delivers two goods: It provides us with a view of natural kindhood that does justice to the epistemic roles of kinds in scientific explanations. And it allows us to solve a problem that HPC theory, currently one of the more popular accounts of natural kindhood, confronts. (shrink)

This essay offers a diagnosis of what may be at stake in the current preoccupation with defining science‐based educational research. The diagnosis unfolds in several readings: The first is a charitable and considerate appraisal that draws attention to the fact that advocating experimental methods as important to a science of educational research is not an inherently evil thing to do. Subsequent readings are grimmer, suggesting more deleterious consequences of the science‐based research movement for the entire enterprise of educational practice and (...) research. The central thesis of the essay is that making arguments about method and science the focal point in the current quarrel may be largely beside the point. Instead, educational researchers should join the political and public conversation about the place of educational science in society and about how science is both implicated in and confronts the politics of what counts as knowledge. (shrink)

Capacitarianism says that an agent can be non-derivatively blameworthy for wrongdoing if at the time of their conduct the agent lacked awareness of the wrong-making features of their conduct but had the capacity to be aware of those features. In this paper, I raise three objections to capacitarianism in relation to its verdict of the culpability of so-called “slips” and use these objections to support a rival (“accessibility internalist”) view which requires awareness of wrong-making features for non-derivative blameworthiness. The objections (...) are that (1) the rival internalist view is just as capable of explaining the culpability of paradigm cases of slips; (2) there are some cases of slips without dispositional awareness of wrong-making features that capacitarians wrongly deem culpable; and (3) capacitarianism cannot adequately ground the reasonable expectation to avoid slips (as Fernando Rudy-Hiller has argued). I then argue that an internalist can simultaneously ground a reasonable expectation to avoid slips and account for slips’ culpability by pointing to the satisfaction of a novel epistemic condition: it is (dispositionally) obvious to the slipping agent that they need to pay enough attention to what they are doing, and how to pay enough attention, to reliably achieve the goal that they have set out to achieve. (shrink)

While evolutionary thinking is increasingly becoming popular in fields of investigation outside the biological sciences, it remains unclear how helpful it is there and whether it actually yields good explanations of the phenomena under study. Here we examine the ontology of a recent approach to applying evolutionary thinking outside biology, the generalized Darwinism approach proposed by Geoffrey Hodgson and Thorbjørn Knudsen. We examine the ontology of populations in biology and in GD, and argue that biological evolutionary theory sets ontological criteria (...) that GD fails to meet. We suggest two options to revise the population concept in GD: reformulating the concept in terms of inheritance and reproduction such that it comes to pick out individuals similar to evolving populations, or trying to build an adequate population concept on a principle of differential retention instead of differential reproduction. 1 Introduction2 Generalized Darwinism2.1 What is generalized Darwinism?2.2 Darwinian principles3 The Ontology of Generalized Darwinism: What Are Populations?3.1 The population concept of generalized Darwinism3.2 The population concept in evolutionary theory4 Locating Evolving Systems in Generalized Darwinism5 Conclusion. (shrink)

Attending closely to Hegel's social, political, and intellectual context, the book begins with Hegel's early concerns with a modern civil religion in the ...

Recent ethnographic studies of lived ethics, such as those of Leela Prasad and Saba Mahmood, present valuable opportunities for comparative religious ethics. This essay argues that developments in philosophical and religious ethics over the last three decades have supported a strong interest in thick descriptions of what it means to be human. This anthropological turn has thereby laid important groundwork for the encounter between these scholars and new ethnographic studies. Nonetheless, an encounter it is. Each side brings novel questions to (...) the other. The second part of the essay focuses on one of these questions: How, exactly, are these ethnographic studies to inform normative reflection on ethical questions? (shrink)

The twelve essays in this volume aim at providing philosophers, neuroscientists, psychologists, and legal theorists with an opportunity to examine the cluster of related issues that will need to be addressed as scholars struggle to come to grips with the picture of human agency being pieced together by researchers in the biosciences.

In Civic Liberalism, prominent political theorist Thomas A. Spragens, Jr. asserts that most versions of democratic ideals—libertarianism, liberal egalitarianism, difference liberalism, and the liberalism of fear—lead our polity significantly astray. Spragens offers another alternative. He argues that we should recover the multiple and complex aspirations found within the tradition of democratic liberalism and integrate them into a more compelling public philosophy for our time—or what he calls civic liberalism.

Organizational ecology is commonly seen as a Darwinian research program that seeks to explain the diversity of organizational structures, properties and behaviors as the product of selection in past social environments in a similar manner as evolutionary biology seeks to explain the forms, properties and behaviors of organisms as consequences of selection in past natural environments. We argue that this explanatory strategy does not succeed because organizational ecology theory lacks an evolutionary mechanism that could be identified as the principal cause (...) of organizational diversity. The “evolution” of organizational populations by means of selection, which organizational ecologists put forward as the mechanism responsible for the extant diversity of organizational forms, is not evolution in any proper sense, because organizational populations do not have what it takes to participate in evolutionary processes. This implies that organizational ecology is not a Darwinian research program and that it cannot explain organizational diversity. (shrink)

Species in biology are traditionally perceived as kinds of organisms about which explanatory and predictive generalizations can be made, and biologists commonly use species in this manner. This perception of species is, however, in stark contrast with the currently accepted view that species are not kinds or classes at all, but individuals. In this paper I investigate the conditions under which the two views of species might be held simultaneously. Specifically, I ask whether upon acceptance of an ontology of species (...) as diachronic segments of the tree of life species can perform the epistemic role of kinds of organisms to which explanatory and predictive generalizations apply. I show that, for species-level segments of the tree of life, several requirements have to be met before the performance of this epistemic role is possible, and I argue that these requirements can be met by defining species according to the Composite Species Concept proposed by Kornet and McAllister in the 1990s. (shrink)

An essential element of human resource management is employee growth and development. Two aspects of this development involve growth in job related behaviours and the less tangible but vital aspect of personal growth. The paper focuses on the latter topic. The aim is an exploration of the relationship between experience and education as they relate to personal growth. Since many schools of management and in-house HRM programmes involve the use of experiential approaches to learning, it seems a relevant issue for (...) discussion. In fact, a strong case is made for the use of experience as a critical part of the personal education and growth process. Logical, rational analysis, poetic device, and teaching stories are used to highlight the role of experience. Extensive use is made of developmental notions from Buddhism, Confucianism, Sufism and Taoism. Reference is made to the Kolb et al. learning cycle model to help examine the personal growth experience. The paper discusses both the role of the educator and the role of the employee or seeker of personal growth. The educational process is discussed in terms of negating as well as affirming, abandoning old ideas as well as gaining new ones. Proposed educational aims for the learner are identified. (shrink)

I provide indestructibility results for large cardinals consistent with V = L, such as weakly compact, indescribable and strongly unfoldable cardinals. The Main Theorem shows that any strongly unfoldable cardinal κ can be made indestructible by <κ-closed. κ-proper forcing. This class of posets includes for instance all <κ-closed posets that are either κ -c.c, or ≤κ-strategically closed as well as finite iterations of such posets. Since strongly unfoldable cardinals strengthen both indescribable and weakly compact cardinals, the Main Theorem therefore makes (...) these two large cardinal notions similarly indestructible. Finally. I apply the Main Theorem forcing extension preserving all strongly unfoldable cardinals in which every strongly unfoldable cardinal κ is indestructible by <κ-closed. κ-proper forcing. (shrink)

Building on influential work in virtue ethics, this collection of essays examines the categories of self, person, and anthropology as foci for comparative analysis. The papers unite reflections on theory and method with descriptive work that addresses thinkers from the modern West, Christian and Jewish Late Antiquity, early China, and other settings. The introduction sets out central methodological issues that are subsequently taken up in each essay, including the origin of the categories through which comparison proceeds, the status of these (...) categories in the process of comparison, and the goals of comparison. In considering the question of goals, the introduction draws connections between comparative study and historical study within one tradition. Both types of analysis can bridge the gap between historical and normative work by attending to the ways in which the questions a scholar asks - not just the answers found - vary from one context to another. (shrink)

We propose, following Clark, that generative models also play a central role in the perception and interpretation of linguistic signals. The data explanation approach provides a rationale for the role of prediction in language processing and unifies a number of phenomena, including multiple-cue integration, adaptation effects, and cortical responses to violations of linguistic expectations.

In Plato’s Protagoras, Socrates argues that ‘the many’ are confused about the experience they describe as ‘being overcome by pleasure’. They think the cause is ‘something other than ignorance’. He argues it follows from what they believe that the cause is ‘ignorance’ and ‘false belief’. I show that his argument depends on a premise he does not introduce but they should deny: that when someone is overcome by pleasure, the desire stems from a belief. To explain why Plato does not (...) make Socrates introduce this premise, the account I construct is speculative. It starts from the assumption that Plato is thinking through an understanding of human beings and what they must do to live good lives that he takes the historical Socrates to set out. (shrink)

There is an interesting parallel between two debates in different domains of contemporary analytic philosophy. One is the endurantism– perdurantism, or three-dimensionalism vs. four-dimensionalism, debate in analytic metaphysics. The other is the debate on the species problem in philosophy of biology. In this paper I attempt to cross-fertilize these debates with the aim of exploiting some of the potential that the two debates have to advance each other. I address two issues. First, I explore what the case of species implies (...) regarding the feasibility of particular positions in the endurantism– perdurantism debate. I argue that the case of species casts doubt on the recent claim that three-dimensionalism and four-dimensionalism are equivalent descriptions of the same underlying reality. Second, and conversely, I examine whether the metaphysical worry about three-dimensionalism and four-dimensionalism can help us to better understand the nature of biological species. I show that analyzing the thesis that species are individuals against the background of the endurantism– perdurantism debate allows us to explicate two different ways in which this thesis can be interpreted. (shrink)

In this target article we question the assumption that perception is divided into separate domains of vision, hearing, touch, taste, and smell. We review implications of this assumption for theories of perception and for our understanding of ambient energy arrays (e.g., the optic and acoustic arrays) that are available to perceptual systems. We analyze three hypotheses about relations between ambient arrays and physical reality: (1) that there is an ambiguous relation between ambient energy arrays and physical reality, (2) that there (...) is a unique relation between individual energy arrays and physical reality, and (3) that there is a redundant but unambiguous relation, within or across arrays, between energy arrays and physical reality. This is followed by a review of the physics of motion, focusing on the existence and status of referents for physical motion. Our review indicates that it is not possible, in principle, for there to be a unique relation between physical motion and the structure of individual energy arrays. We argue that physical motion relative to different referents is specified only in the global array, which consists of higher-order relations across different forms of energy. The existence of specificity in the global array is consistent with the idea of direct perception, and so poses a challenge to traditional, inference-based theories of perception and cognition. However, it also presents a challenge to much of the ecological approach to perception and action, which has accepted the assumption of separate senses. (shrink)

This chapter examines the status of psychopathy as a scientific kind. I argue that the debate on the question whether psychopathy is a scientific kind as it is conducted at present (i.e., by asking whether psychopathy is a natural kind), is misguided. It relies too much on traditional philosophical views of what natural kinds (or: legitimate scientific kinds) are and how such kinds perform epistemic roles in the sciences. The paper introduces an alternative approach to the question what scientific (or: (...) natural) kinds are. On this alternative approach, the Grounded Functionality Account of natural kinds, psychopathy emerges as a “good” scientific kind that is best understood as a region on a multidimensional space of behaviors rather than as a traditional natural kind. (shrink)

This paper explores how work in the philosophy of science can be used when teaching scientific content to science students and when training future science teachers. I examine the debate on the concept of fitness in biology and in the philosophy of biology to show how conceptual pluralism constitutes a problem for the conceptual change model, and how philosophical work on conceptual clarification can be used to address that problem. The case of fitness exemplifies how the philosophy of science offers (...) tools to resolve teaching difficulties and make the teaching of scientific concepts more adequate to the actual state of affairs in science. (shrink)

Keith DeRose gives an invalid argument for contextualism in “Assertion, Knowledge, and Context.” In section 2.4, entitled “The Argument for Contextualism,” DeRose makes the following remarks. “The knowledge account of assertion provides a powerful argument for contextualism: If the standards for when one is in a position to warrantedly assert that P are the same as those that comprise a truth-condition for ‘I know P,’ then if the former vary with context, so do the latter. In short: The knowledge account (...) of assertion together with the context-sensitivity of assertability yields contextualism about knowledge”. (shrink)

Evolutionary explanations are not only common in the biological sciences, but also widespread outside biology. But an account of how evolutionary explanations perform their explanatory work is still lacking. This paper develops such an account. I argue that available accounts of explanations in evolutionary science miss important parts of the role of history in evolutionary explanations. I argue that the historical part of evolutionary science should be taken as having genuine explanatory force, and that it provides how‐possibly explanations sensu Dray. (...) I propose an account of evolutionary explanations as comparative‐composite explanations consisting of two distinct kinds of explanations, one processual and one historical, that are connected via the explanandum's evolvability to show how the explanandum is the product of its evolutionary past. The account is both a reconstruction of how evolutionary explanations in biology work and a guideline specifying what kind of explanations evolutionary research programs should develop. (shrink)

Examines the relationship between the question of God and the destiny of metaphysics. Concept of the end of metaphysics; Ambiguous relation between phenomenology and metaphysics; Return of special metaphysics in phenomenology; Phenomenological figure of God. Examines the relationship between the question of God and the destiny of metaphysics. Concept of the end of metaphysics; Ambiguous relation between phenomenology and metaphysics; Return of special metaphysics in phenomenology; Phenomenological figure of God.